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Ayurveda, the ancient science of life, describes Visha (toxic substances) as agents capable of disturbing the normal physiological and biochemical functions of the body, ultimately leading to disease and even death if not managed appropriately. Among the various branches of Ayurveda, Agada Tantra deals specifically with the identification, classification, pathogenesis, prevention, and treatment of toxic substances. Classical Ayurvedic texts not only discuss acute poisoning caused by natural toxins (Sthavara and Jangama Visha) but also provide a detailed description of chronic and cumulative toxic states under the concept of Dooshi Visha. Dooshi Visha refers to residual toxins that remain concealed within the body for prolonged periods, gradually affecting different tissues (Dhatus) and physiological systems. According to Ayurvedic principles, these toxins predominantly vitiate Rasa, Rakta, Mamsa, Artava, and Shukra Dhatu, thereby impairing reproductive health and adversely influencing the quality of offspring. The concepts of Beeja (sperm and ovum), Beejabhaga (chromosomal components), and Beejabhagavayava (genetic subunits) described in Ayurveda indicate an advanced understanding of heredity and congenital abnormalities. Classical texts mention that the vitiation of Shukra and Artava by toxic substances can result in infertility, recurrent abortions, fetal malformations, developmental abnormalities, defective progeny, and hereditary disorders. Furthermore, prolonged exposure to incompatible diet (Viruddha Ahara), environmental pollutants, contaminated food, artificial additives, chemicals, and chronic toxins has been conceptually linked with Dooshi Visha, producing systemic and reproductive dysfunctions that may persist across generations. From a modern scientific perspective, reproductive toxicity encompasses adverse effects on sexual function, fertility, hormonal regulation, conception, pregnancy maintenance, embryonic development, and postnatal growth. Similarly, genetic toxicity (genotoxicity) refers to damage inflicted on genetic material, including DNA mutations, chromosomal abnormalities, epigenetic alterations, and heritable genetic defects. Increasing industrialization, environmental contamination, excessive pesticide use, heavy metal exposure, food adulteration, pharmaceutical misuse, radiation exposure, and unhealthy lifestyle practices have significantly contributed to the rising prevalence of infertility, congenital anomalies, endocrine disorders, reproductive dysfunction, and genetic diseases worldwide. Modern toxicological research has demonstrated that chronic low-dose exposure to toxic substances can impair gametogenesis, disrupt endocrine pathways, induce oxidative stress, alter gene expression, damage reproductive organs, and adversely affect fetal development. These findings closely resemble the Ayurvedic description of Dooshi Visha and its long-term effects on reproductive tissues and progeny. The present review critically examines the Ayurvedic concepts of Visha and Dooshi Visha in relation to genetic and reproductive manifestations described in classical texts of Agada Tantra. It further explores the correlation between Ayurvedic principles and contemporary concepts of reproductive and genetic toxicology, including infertility, teratogenicity, mutagenicity, endocrine disruption, congenital malformations, and transgenerational inheritance. Particular emphasis is placed on understanding how chronic toxic exposure affects Shukra and Artava Dhatu, influences fetal development, and contributes to hereditary disorders. The review also highlights the relevance of Ayurvedic detoxification measures, preventive strategies, and lifestyle modifications in minimizing toxic burden and preserving reproductive health. By integrating the classical wisdom of Ayurveda with contemporary scientific evidence, this review attempts to establish a conceptual bridge between Agada Tantra and modern toxicology. Such an interdisciplinary approach may enhance the understanding of toxin-induced reproductive and genetic disorders, provide novel insights into preventive healthcare, and promote the development of integrative strategies for safeguarding reproductive health and ensuring healthy progeny in the modern era.