Volume 12 | Issue 9 |

 Abstract

Today, the new approach to pharmaceutical quality is called Quality by Design. The following paper provides an overview of pharmaceutical quality by design (QbD) and explains the various software tools and applications that are employed in QbD.The goal of pharmaceutical development is to create high-quality products and manufacturing processes that reliably produce the desired results. Products cannot be assessed for quality; instead, quality should be included into the design. The study analyses the current QbD-assisted software's, such as design- experts, Minitab fusion product development

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In the era of digital media, the rapid increase in video content generation and consumption poses a significant challenge for users seeking to extract valuable information efficiently. This project aims to develop an AI-powered real-time video summarization system that leverages advanced machine learning and natural language processing techniques to provide concise and accurate summaries of YouTube video content. By integrating OpenCV for video processing, deep neural networks for feature extraction, and state-of-the-art NLP models for summarization, the system generates brief summaries highlighting key points and essential information. Utilizing Streamlit for a user-friendly web interface, the system is designed for scalability and performance, ensuring it can handle diverse video types and lengths while delivering prompt summaries to enhance users' ability to quickly grasp video content.

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Video Summarization, Deep Learning, Natural Language Processing, Machine Learning, OpenCV, YouTube Data API, Streamlit, Deep Neural Networks, Feature Extraction, Text Summarization, Automatic Speech Recognition, Extractive Summarization, Abstractive Summarization, Video Processing, Real-time Systems

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Oral mucositis is a common, debilitating symptom affecting many patients on high-dose chemotherapy. It has been shown to affect 5-15% of patients undergoing cancer treatment in general, but with certain agents such as 5-florouracil (5FU), the rates are much higher, approaching 40-50%. Statement of the Problem: A study to assess the effectiveness of ice cube application in reducing oral mucositis among chemotherapy receiving patients in selected hospital at kanyakumari district. Objectives: To assess the level of oral mucositis before the application of ice cubes among chemotherapy receiving patients with cancer. To assess the level of oral mucositis after the application of ice cubes among chemotherapy receiving patients with cancer. Methodology:This study adopts quasi experimental design with pretest and post test control group design. Data was collected from 40 samples by simple random technique. The tool used for data collection include: Selected demographic variables, World Health Organization (WHO) scale gradings. All tools were validated and subjected to reliability testing. Pilot study was conducted to find out the feasibility of the study. The tool was administered and data was collected for 6 weeks from 40 samples and the data obtained were classified, grouped and analyzed based on the objectives and hypotheses formulated for the study using descriptive and inferential statistics. Results: In experimental group 35% of sample subjects had normal and mild oral mucositis, 20% had moderate and 10% severe erythema, were as in control group 40% of sample subjects had extreme oral mucositis, 30% had severe, 20% had moderate and 10% had mild erythema. The mean oral mucositis score in experimental group (1.0) was greater than the mean oral mucositis score of the control group (0.8). The mean difference was (0.2) and was significant at (P<0.001) level. Conclusion: The study findings revealed that, there was a high significance in reduction of oral mucositis among chemotherapy receiving patients after application of ice cubes in experimental group than control group. Thus ice cube application played an important role in reducing oral mucositis among chemotherapy receiving patients.

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Oral mucositis, ice cube application, chemotherapy

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The emergence of cloud computing has revolutionized the Information and Communication Technology landscape, offering a cost-effective and scalable solution for the on-demand provision of computing resources. Organizations are increasingly drawn to the cloud for outsourcing their computational requirements, benefiting from minimal upfront investment. Central to this paradigm are Service Level Agreements (SLAs), which ensure Quality of Service (QoS) between cloud providers and users. The breach of SLAs can result in contractual penalties and revenue loss, underscoring the criticality of effective SLA management for cloud providers. This involves continuous monitoring and control of various SLA parameters to prevent violations. To address this challenge, there is a growing need for proactive measures to anticipate and mitigate potential breaches by predicting SLA parameter values based on continuous monitoring data. In this research, we propose an agent-based SLA management framework featuring a coordinator agent designed to employ predictive modeling techniques for pre-emptively identifying and addressing SLA violations. Our approach is substantiated by a case study utilizing real-world datasets, demonstrating the efficacy of predictive modeling in enhancing SLA management within cloud environments.

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Service Level Agreement (SLA), Cloud computing, Agent based Computing. Multi agent system (MAS)

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Hypertension (HTN) is taken into consideration one of the main reasons of extended cardiovascular disease. Lowering blood stress does lessen cardiovascular risks; retaining systolic blood stress of much less than a hundred thirty mm Hg screen prevents headaches in sufferers with coronary heart failure, diabetes, coronary artery disease, stroke, and different cardiovascular diseases. This hobby discusses the pointers for deciding on the correct antihypertensive medicinal drugs . It affords the one-of-a-kind training for first, second, and third-line remedies for high blood pressure and highlights the indicators and aspect effects. It highlights the research completed to evaluate one-of-a-kind training of antihypertensive medicinal drugs and indicators for every magnificence .The 2017 American College of Cardiology (ACC) and American Heart Association (AHA) definition of HTN tiers is: Normal blood stress (BP): systolic BP is much less than a hundred and twenty , and diastolic BP is much less than eighty .Elevated BP: systolic BP is a hundred and twenty to a hundred thirty , and diastolic BP is much less than eighty . Stage 1 HTN: systolic BP a hundred thirty to 139 or diastolic BP eighty to 89. Stage 2 HTN: systolic BP as a minimum a hundred and forty or diastolic as a minimum 90. Hypertensive crises: systolic BP over a hundred and eighty and/or diastolic BP over a hundred and twenty . In the 2019 ACC/AHA Guideline at the Primary Prevention of Cardiovascular Disease, all sufferers with extended blood stress are encouraged to have life-style adjustments as preliminary remedy , which includes weight loss, a healthful coronary heart diet, extended bodily hobby , a low sodium diet, and dilemma of alcohol consumption.

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Tachycardia, B-blocker, Thiazide, Channel blocker, Dbumetanide, Torsemide

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This paper attempts to study the role of women in recreating the space in the process of resettling in the outskirts of Calcutta. If Partition has destroyed a whole generation of women, it has also provided an opportunity for many women to move into the public sphere which was even unimaginable to many women before Partition. Such large-scale displacement of women made the country think about workplaces where women were a new presence and on political mobilization where women began to participate in great numbers. not all women welcomed this newfound independence. This individual freedom was also a form of slavery, a burden which one can neither carry, nor avoid. Women's dominion, sphere, and location have always been inside the house and have been connected, across time and cultures, to a private world apart from a public one inhabited by males. Compared to their male compatriots, women were far more vociferous. Since they were more receptive to criticism and more eager to speak out against the system when surrounded by supportive individuals, refugee women were the first to organise. Even the screaming fits that hungry kids would throw at home had to be dealt with. This is how women started to take care of both the outside world and their homes. Hindu refugee women gradually started to make their public debuts.

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refugee, women, partition, public, workplace

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Abstract: The period before parturition is honoured as a precarious occasion, posing raised troubles for the emergence of psychiatric conditions, whether pre-existing or recently evolved. On a global scale, current mental health conditions similar to depression and anxiety significantly contribute to maternal morbidity and mortality, representing a substantial challenge. This burden is particularly pronounced in low- and middle-income nations. Objectives: 1. To assess the level of anxiety and depression among antenatal mothers. 2. To assess the correlation between anxiety and depression among antenatal mothers. 3. To find the association between the level of anxiety and depression with selected demographic variables among antenatal mothers. Methodology: A quantitative research approach and descriptive research design was used. 100 antenatal mothers from Antenatal OPD, Thiruvallur Government Medical College and Hospital, were selected as a study sample by using a non-probability purposive sampling technique. The investigator collected data using the self-administered Perinatal Anxiety Screening Scale (PASS) and Edinburg Postnatal Depression Scale (EPDS) to assess anxiety and depression among antenatal mothers. The data was analysed using descriptive and inferential statistics. Results: The study results showed that the majority 73(73%) had mild to moderate anxiety, 17(17%) had asymptomatic, and 10(10%) had severe anxiety. While 35(35%) had likely not had depression,25(25%) had probable depression and 10(10%) had a fairly high possibility of depression. While positive correlation (r=0.708) between anxiety and depression. Conclusion: The findings of the study indicated that most mothers experienced anxiety and depression during pregnancy and also reveal a positive correlation between anxiety and depression. The study finding highlights the importance for healthcare professionals and policymakers to screen for mental health issues, implement targeted interventions, and enhance antenatal care services.

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Antenatal Mother , Anxiety, Depression

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This paper provides a detailed analysis of the increasing crimes against women in India, focusing on data from the 2023 National Crime Records Bureau (NCRB) report. It explores the trends and patterns in gender-based violence, including domestic violence, cybercrime, and sexual offenses. The paper also discusses regional disparities in crime rates and examines the socio-economic and cultural contexts that contribute to these crimes. By utilizing a multi- faceted approach, this study highlights the need for more effective policies, legal frameworks, and support systems to combat crimes against women. The findings emphasize the importance of future research and targeted interventions to address the root causes of gender- based violence.

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Crimes Against Women, Gender-Based Violence, NCRB 2023, Cybercrime, Domestic Violence, Socio-Economic Factors, India

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The concept of one country, one election in the federal system of India: a critical study.

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The concept of one country, one election in the federal system of India: a critical study.

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The management of electronic resources (e-resources) in academic libraries is pivotal in enhancing research and educational outcomes. This study explores the strategies and effectiveness of e-resource management in selected university libraries across Telangana State, India. The study focuses on how libraries acquire, access, integrate e-resources, and the challenges faced by the University Libraries. The study utilizes a mixed-methods approach, incorporating surveys, interviews, and direct observation to gather data from librarians and users within the university libraries. Key focus areas include the impact of technological infrastructure, budget allocations, staff competencies, user engagement on the overall management and utilization of e-resources. The study reveals a significant variation in the management practices between different university libraries, influenced by financial, technical, and human resource factors. While some libraries demonstrate robust systems and policies for managing e-resources efficiently, others struggle with issues such as inadequate funding, limited technical support, and lack of training for library staff. The study suggests that enhancing digital literacy skills among librarians and users, increasing budget allocations for digital resources, and adopting advanced technological tools are critical for improving the management of e-resources in university libraries. The study concludes with a set of recommendations tailored for policymakers, library administrators, and academic institutions in Telangana to optimize their e-resource management strategies to better support their academic communities.

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e-resource management strategies, University Libraries, Telangana, OPACs (Online Public Access Catalogs)

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