Volume 8 | Issue 6 |

 Abstract

The Bilayered tablets containing Dasatinib SR and Dasatinib IR were successfully prepared by direct compression and wet granulation method respectively. The physiochemical evaluation results for the granules of all trials pass the official limits in angle of repose, compressibility index The physiochemical evaluation results for the dry blend of all trials pass the official limits in angle of repose, compressibility index. The prepared blend for IR relaese were also maintained the physiochemical properties of tablets such as thickness, hardness, weight variation, friability. The optimized formulation contains the average thickness of 2.58�0.66, average hardness of 4.6�0.57, average weight of 183�1.14 mg, friability of 0.34 and 100.24�1.25%. The prepared dry mixer for sustained release were also upheld the physiochemical properties of tablets such as thickness, weight variation, friability. The optimized formulation contains the average thickness of 3.80�0.80, average hardness of 7.6�0.40, average weight of 178�0.54, friability of 0.36. In the F3 trial, the optimized formulation was F3 trial which releases the dasatinib in sustained manner in 1st hour it releases 28 % but the remaning drug release was sustained up to 12 hours and dasatinib immediate release with in an 20min since the tablet disintegrated within 2 minutes 12 seconds.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Dasatinib, compressibility index, sustained release.

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Creative Commons Attribution 4.0 and The Open Definition

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The article aims to predict a level of stress by assessing the individual's activities. This is done through the use of a sensor that is mounted on a glove. The motion sensor selected for this project was chosen as compared to a physiological signal, due to its low cost and the fact that it is least affected by environmental factors. The main cause of accidents nowadays is the increased level of stress on the crew members. The physiological signal measurements using the sensors are mandatory for measuring the stresses of the crew member. This paper presents the concept of predicting the stress level of the crew members based on heart beat rate and body temperature. This is achieved through the use of temperature sensor, IR sensor and heartbeat sensor, which is placed in the gloves worn by the crew members. The GSM module transmits the total readings to the mobile unit. The crew members 'self-reports are used as the basis for estimating the crew members' stress levels. Infrared sensor is used for accident prevention. If there is an irregular condition in the pilot's heartbeat the flight is switched to automatic mode. Then the person's current status is sent out using GSM. The readings of the sensors used above revealed that exact values could be obtained. This shows the need to include the temperature sensor, IR sensor, pulse sensor for tracking the stress level of the crew members.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Temperature sensor, IR sensor, Heartbeat sensor, stress monitoring, wearable system.

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Creative Commons Attribution 4.0 and The Open Definition

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This study aimed to analyze the prevalence of role conflict among the nursing professionals of multispecialty medical college hospitals of Dakshina Kannada district in Karnataka state. There is a need to highlight the problem of nurses who play an important role in providing healthcare to the community. Thus a sample of 500 respondents selected through simple random method showed that majority of nurses had moderate level of role conflict (72.2%). An integrated coherent framework of specific strategies are needed to reduce their job stress and role conflict.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Nursing professionals, Role conflict

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Since the development of urbanization in the world. The construction has increased rapidly. The increase in demand of construction leads to the production of Co2 in the environment. About 7% of the environmental pollution is due to cement manufacturing industries. Thus to lower the amount of objective to do this in concrete is as the dumping of rice husk has been a problem where it leads to problem in land cover and its nature of light weight made this to produce the polluted particles into environment. Also, the husk ash contains silicon which is a major constrain that material strong and fineness equal to cement. Here in, we had a problem as rice husk don�t have the properties of the binding when mixed with water. So, as a concern there placement is limited to 5%, 10% and 15%. Thus mixed concrete is allowed to curing after passing its fresh stage tests. After curing the major mechanical property, compression, tensile and flexure test, where as these are the major test that defines the quality of the concrete. The final aim of the project is produce a concrete that is environmentally free and structurally strengthen concrete.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Light weight concrete, Rice husk ash Concrete, Compression, Environmental free Concrete.

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

The role of ion channels in the development of different cancer has become a novel area of research. There are so many ion channels which are responsible for cancer like phenotype. Among all chloride ion channel is considered to be one of the most active channels along with potassium in case of tumor genesis. High rates of proliferation, active migration, and invasiveness are all hallmarks of cancer which are caused due to channelopathy. It is known that all this action requires action of chloride channel activity as well as the action of ANOCTAMIN genes, which controls the expression of chloride channels in cancer. As the chloride channels involvement is very essential for cancer cell, and as it is known that the abnormal activity of chloride channels can promote the cancer so they can be used as possible aims to cure cancer. Here in this reviewthe chloride channels how they can acts as biomarkers of cancer and specifically which channels are responsible for cancer and ways of linking it for developing anti-tumor drugs will be discussed.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

CLIC, CLCA, Oncochannelopathy, Tumorigenesis, Anoctamins.

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Creative Commons Attribution 4.0 and The Open Definition

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Seat belts or safety belts are important for automobile vehicles. The webbing plays an important role in the properties of the seat belts. The structure and type of fabric improves the performance of the seat belts. The various seat belts, the seat belts with energy storing properties, seat belts with load sensitive properties, seat belts with printed face and back and woven seat belts are available. In this review, the production of the above seat belts are described.

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Creative Commons Attribution 4.0 and The Open Definition

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Seat belt, webbing, non woven, woven, braiding, safety, performance, production.

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Creative Commons Attribution 4.0 and The Open Definition

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This article discusses the way at validating a Measurement for the ramifications of armed conflict that impact in the different aspects of the basic needs for human life in society. the sample included (443) students and academics in three universities in Yemen, Malaysia, and Gaza Palestine. The students and academics sample chosen are from Arab the belong to countries where armed-conflict is quite dominant in during this period, The researchers followed several steps in order to validate the Measurement. These steps included (1) formulating the Measurement elements, (2) verifying the validity of the apparent consistency of the questionnaire by presenting it to the arbitrators from professors specializing in the fields of management, education and statistics and (3) using exploratory factor analysis (EFA) ) by the Statistical Package for Social Sciences (SPSS) to examine the validity Internal consistency, and analysis of correlation coefficients between variables on the Measurement, and relying on the Kaiser criterion for generating and extracting factors that exceed or equal its latent roots 1. Factor Confirmation Analysis (CFA) using the AMOS program for underlying factors that constitute a set the Measurement of this study, where the tables of standard regression weights and multiple square correlations revealed each for each item that each factor is one-dimensional. By the modelling of the structural equation (SEM) has been verified Convergence validity, differentiation validity, and compound reliability for concepts stability. The results of the study denoted that the Measurement in its final form contained (43) items distributed over six factors, according to accurate statistical treatment, and it was excluding (7) items that did not meet the standard conditions in the two programs.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

A Measurement of Ramifications, Armed conflicts, Basic Needs Fields, Humans Life

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Guava is a significant food crop also as restorative plant observed tropical and subtropical areas. Psidium guajava linn. is an individual from Myrtaceae family, which contains 133 genera and excess of 3,800 plant species. Guava is wealthy maximum of phenols, triterpenes, flavonoids, oils, saponins, lectins, vitamin-c and fiber. The leaf of guava is reach source of flavonoids specifically quercetin, kamiferol luteol. The guava is helpful to increase bowel movement is ascribed due to favonoids and fibres. The flavonoids have pharmacological activity like antibacterial, antioxidant, hepatoprotective. In isolation of quercetin separate form from leaves of Psidium guajava l. by using methanol and fallowed the different chemical and analytical test like Lead acetic acid derivation test, Sodium Hydroxide test and Shinoda test , thin layer chromatography mobile phase was Ethyl acetate: Formic acid: GAA: Water, and different procedures UV, IR, NMR, HPLC and HPTLC of Quercetin was studied .

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Creative Commons Attribution 4.0 and The Open Definition

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Guava is a significant food crop also as restorative plant observed tropical and subtropical areas. Psidium guajava linn. is an individual from Myrtaceae family, which contains 133 genera and excess of 3,800 plant species. Guava is wealthy maximum of phenols, triterpenes, flavonoids, oils, saponins, lectins, vitamin-c and fiber. The leaf of guava is reach source of flavonoids specifically quercetin, kamiferol luteol. The guava is helpful to increase bowel movement is ascribed due to favonoids a

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Tourism is a short time movement of people from one place to another place which have travelling for fun. People who travel for fun are called tourists. Tourism is now a day considered as an important industry which has vast scope for the generation of income and employment. It is one of the world�s fastest growing industries. A major source of foreign exchange earner of a nation. The state of Bihar specially mithilanchal is best known for its unique Madhubani Art ( Mithila Painitng ) . A Phullahar the village contains the temple of goddess Girija, Ahilya Asthan (Darbhanga), Maa Janki (Sita) Janam sthali Punaura Dham (Sitamarhi), Halewhwar Asthan (Sitamarhi) , Shyama Mai Temple ( Darbhanga) and many more. Although the whole north region of Bihar has tremendous potential, the tourism industry in the area is still miles to go to exploit the proper potentialities. The state as well as the entire northern region of India has subjected to century long neglect, even after 71 years of the country�s independence. The present paper has been an attempt to highlights the main prospects and problems of tourism in mithilanchal, Bihar

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Tourism, Famous tourist place, Development.

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Paperless Operation has become a very big matter of fact and demand of the society in this fast growing world around us. With increasing population and proportionally increasing services day by day it is ethically very hard to accommodate every single transaction with a piece of paper because that costs a number of trees to the environment. As this rapid cutting of trees have adverse effect on environment and the ecological balance. To solve such problem we need paperless technologies. Digi-Sign is a digital signature system that facilitates creation of digital signatures for documents online, and also facilitates users to communicate online with the help of AES methodology. It also allows status tracking of the document and empowers the owner to maintain the same. Digi-Sign has built in features which allows feasibility of operation with digital signatures and also allows faster creation of signature keys alongside provide instant verification of document online. It binds every single signatory and addressee together into a same network for faster communication that has never been possible before. Digi-Sign do not encrypt the entire document, it creates signatures using basic information of any document. It hosts a public database to index the all the documents created by various owner in one place. That helps easy accessibility for validation of information about any document.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

AES, Encryption, Digi-Sign(digital signature), centralized Database.

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Creative Commons Attribution 4.0 and The Open Definition