Volume 11 | Issue 6 |

 Abstract

Chronic Kidney Disease (CKD) is a global health problem with a high morbidity and mortality rate. In such a disease, there are very few symptoms at an early stage; however, as time passes, the disease results in several damages. Early detection of CKD enables the patient to receive timely treatment and gives them a chance to minimize the damage. The proposed project aims to use a combination of Logistic Regression and Random Forest algorithms for detecting CKD. According to the literature survey, the combination of Logistic Regression Random Forest yields the best accuracy. Voting classifier is used to ensemble both the algorithms. Hence, machine learning methodology is employed, and the CKD dataset from the University of California Irvine (UCI) is used for training and detecting CKD in the early stage.

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 Keywords

Chronic Kidney Disease, Logistic Regression, Random Forest, KNN

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Ayurveda is a traditional medicinal system of Indian sub- continent followed by centuries together by the people of India. Rasa shastra is the latrochemistry of Ayurveda which deals with the formulations containing herbals, metals & minerals. Various Kalpanas like Kharaliya Kalpana, Parpati Kalpana, Pottali Kalpana, Dravaka Kalpana etc are mentioned in Classical text of Rasa Shastra. Shankha Drava is one such Dravaka Kalpana which one mentioned in our classics. It is a liquid preparation obtained by processing of Lavana (salt) and Ksharas (alkaline materials) by distillation process. In this era of globalization it is the need of time to explore the scientific bases of procedures and medicaments of Ayurveda. The primary responsibility of the Ayurveda fraternity is to establish the scientific information regarding the preparation of the medications.

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 Keywords

Dravaka Kalpana, distillation process, Lavana, Kshara

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CONSTRUCTING ENVIRONMENTAL HISTORY Extract Construction of Environmental history has emerged one of the most challenging and daunting task in front of the researchers. Equally, this is most thrilling sub- discipline of history where a researcher tries to explore with not only the long duree' / long duration [geographical structures, the seas, the mountains or the so-called biological determinants],medium duree or short duree but also thermometric analyses, climate biology, historical geography and demography, climatic change, glaciology[to measure the changes in the surface of glaciers or the density of the ice, geomorphology [study of moraines or depositions of rocks and soil by the glaciers], palynology[ study of marshes and peat bags situated downstream of the glaciers, plant pollens], dendrochronology study of the rings of the trees], Aurora Borealisto Minimum Maunder or the Little Ice Age but also nuclear biology to C14,which is devoid of monotony of dynastic exaggerations or literary interpolations or tampering with the numismatic or material sources. This term paper 'Constructing environmental History' is tended to open new vistas in the field of interdisciplinary historical research.

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 Keywords

Ecological Imperialism, Maunder Minimum, dendrochronology, palyonology, LittleIce Age, Tambora,La Logue Duree'

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Type 2 diabetes mellitus (T2DM) is a prevalent condition influenced by genetic and environmental factors, leading to various complications such as retinopathy, nephropathy, neuropathy, cardiovascular events, atherosclerosis, and increased susceptibility to infections. This systematic review examines the relationship between methylenetetrahydrofolate reductase (MTHFR) gene methylation and T2DM, emphasizing its clinical significance and complications. MTHFR gene variants, particularly the C677T polymorphism, have been associated with an elevated risk of T2DM, especially in Asian populations. Methylation patterns within the MTHFR gene, in combination with specific genetic variations, have been linked to metabolic parameters and the development of microvascular complications in individuals with diabetes. Understanding the impact of MTHFR gene methylation on T2DM pathogenesis can aid in risk assessment, diagnosis, and personalized treatment strategies. The review discusses the underlying mechanisms by which MTHFR gene methylation may contribute to diabetes pathophysiology, as well as its potential implications for risk assessment and diagnosis. Moreover, further investigation is needed to explore the potential of MTHFR gene methylation as an early detection marker for assessing complications and enhancing diagnostic strategies of T2DM. The review emphasizes the need for further research to gain a comprehensive understanding of the intricate relationship between MTHFR gene methylation and diabetes. Additionally, exploring the potential of MTHFR gene methylation as an early detection marker for complications and improving diagnostic strategies in T2DM warrants further investigation.

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 Keywords

MTHFR gene, Methylation, Diabetes mellitus, Pathophysiology, SNPs

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Creative Commons Attribution 4.0 and The Open Definition

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The article discusses the impact of technology on libraries and the advantages of digital resources and consortia in library collection development. It emphasizes how libraries are leveraging technology to upgrade their services and divide libraries into categories such as hybrid libraries, electronic libraries, digital libraries, and virtual libraries. The concept of digital resources is explained, referring to information sources in digital format such as databases, books, journals, newspapers, and more. The advantages of digital resources are highlighted, including the ability to access information from anywhere at any time, multiple simultaneous accesses, structured content, easy information retrieval, preservation without degradation, space efficiency, and cost considerations. The Article also mentions the factors that influence collection development, such as increasing user demand, rising document costs, and limited library budgets. To overcome these challenges, libraries can form consortia, which involve groups of libraries coming together to share resources and achieve common goals. The concept of consortia is defined as a partnership or association of libraries to participate in resource sharing. It is explained that consortia have long been used to improve access and service through methods like interlibrary loan, document delivery, and institutional membership. Consortia can be formed at various levels and may focus on specific functions or subjects. The advantages of consortia-based collection development include wider access to electronic resources at lower costs, optimum fund utilization, support for building digital libraries, enhanced library services, cost sharing for technical support, better license terms, and continuous availability of resources. Overall, the article provides an overview of how technology and digital resources are transforming libraries and the role of consortia in facilitating resource sharing and cost-effective collection development.

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Consortia, Collection Development, Resource Sharing, Digital Libraries.

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

The flat slab system has become increasingly prevalent in modern building construction due to its ability to satisfy economic and architectural demands by reducing floor heights. Compared to conventional moment resisting frames, reinforced concrete buildings utilizing flat slabs exhibit numerous advantages. Despite the fact that flat slab construction offers several advantages over conventional moment resisting frames, its ability to withstand seismic loading is limited, thus reducing its overall structural effectiveness. Despite numerous studies conducted by various authors in recent years, the behavior of flat slab structures under lateral-displacements remains poorly understood. Nevertheless, flat slabs continue to be popular even in areas prone to earthquakes. This present study involves the analysis and comparison of a 12-story flat slab reinforced concrete structure with vertical and mass irregularities subjected to lateral loads according to IS codes. The primary objective of this work is to analyze and compare irregular flat slab reinforced concrete structures with and without lateral force resisting systems, such as shear walls and bracing systems. Etabs software is utilized to conduct the structural analysis. For structures with vertical irregularities, dynamic analysis is carried out in accordance with IS 1893:2002 (part 1), and various parameters, including base shear, time period, story drift, story displacement, and story stiffness, are compared for these structures.

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Flat Slab, Seismic loading, Irregular building, Shear Wall, Bracing, Etabs.

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Creative Commons Attribution 4.0 and The Open Definition

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Synectics is a creative way to learn new information or solve complex problems. Synectics incorporates new concepts in what the learner already knows, which increases the transfer of knowledge. The Synectics Model of Teaching is used in fostering Creative thinking Skills in Science Fig 1: Instructional and Nurturant Effects of the Synectics Model of Teaching This model of teaching consists of two approaches Making Familiar Strange (MFS)- Learner oriented and Making Strange Familiar (MSF)- Instructor oriented. The researcher has taken strategy II Making Strange Familiar to foster Creative Thinking Skills in Science among students at the middle school level. The metaphoric activity in Synectics renders creativity to emerge as a conscious process. It frees the participant himself to develop imagination and insights into everyday activities.

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Synectics, Model of teaching, Creative Thinking Skills, Middle School

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Creative Commons Attribution 4.0 and The Open Definition

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There has been a noticeable increase in the occurrence of autoimmune diseases over the years, and this trend cannot be solved due to the failure of finding new treatment strategies. Despite the availability of established protocols for managing autoimmune infections, the protocols of oncology, metabolic diseases, and transplantation are often employed as paradigms for handling autoimmune diseases (AD). Glucocorticoids, widely prescribed drugs for autoimmune conditions, exhibit rapid and extensive effects on immune cells. Nevertheless, the long-term use of glucocorticoids has been associated with specific toxicities. Therefore, this review emphasizes the exploration of natural anti-inflammatory steroid alternatives that draw upon the traditional utilization of medicinal plants and herbal products. Consequently, investigating medicinal plants as a valuable source of potent anti-inflammatory agents holds significant importance and warrants further exploration in novel drug design.

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Autoimmune diseases, Herbal extracts, Medicinal plants, Natural active compounds, Natural anti-inflammatory sources

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Creative Commons Attribution 4.0 and The Open Definition

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Conflicts are going all around the world. Different region has different issues and various players involved. But one region which has constantly been significant in present geopolitical context is "Eastern Mediterranean". Maintaining is legacy of 60s and 70s the region has still burning and sitting on a volcano. It has seen a different variety of conflicts, religious, ethnic, racial, territorial etc. And there is big fist fight going on over resources. Turkey, Israel, Cyprus, Libya, Lebanon, Egypt, Syria and many more foreign players are strategizing their plans to get hold on these unexplored resources. The huge pile of gas reserve has potential to fulfil demands of clean energy and make these small states rich as never before. This ongoing tussle can be theorized with the decentralization of International Order as the players involved are strong and weak with this region. They are no longer subordinate to any "poles". This has been seen when Armenia and Azerbaijan locked their horn recently over areas of Nagorno-Karabakh. Two forces working simultaneously are decentralisation and regionalisation. The idea has grown stronger in present time. Whether it's a matter of security, economy, migration, or now a day's pandemic. Regions tend to work cohesively among their member nations. A lot is happening in Mediterranean Sea. Through these lenses this paper will try to explore the potential energy reserves in Eastern Mediterranean and their significance in changing geopolitics of the region. And how regional and international states are formulating their policies.

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 Keywords

Keywords: Abuse of authority, Corruption, Law, Government Administration, Resource based conflict, Eastern Mediterranean

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

There is no adequate yield from the majority of Indian agricultural fields since they are divided into little acres of land. This is due to the crops being grown on small plots of land, which results in less crop production. The goal of this project is to combine small agricultural plots into larger agricultural plots. The farmers will gather together and consolidate the nearby properties. Once they sign a contract with the farmer organisation, agricultural machinery suppliers will also become a member of the group. Farmers might get financial assistance as well. The financial support may come from banks, businesses, and government initiatives. The industries will come to a deal, offer financing, and also purchase their goods or products. farmers will access

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 Keywords

Blockchain,Ledger,Decentralisation,cryptographic

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