Volume 11 | Issue 6 |

 Abstract

HIGHWAY PROJECT

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HIGHWAY PROJECT

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Creative Commons Attribution 4.0 and The Open Definition

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The relationship between music training and self-esteem and emotional development has been a topic of interest in psychological and educational research for decades. Studies have suggested that engaging in music training, such as playing an instrument or singing, can have a positive impact on individuals self-esteem and emotional well-being. The present study found a positive relationship between music training with self esteem and emotional intelligence. The study aims to further explore this connection given the possible advantages of music instruction on emotional growth and self-esteem. Important ramifications for education, therapy, and mental health can result from a better understanding of how music instruction might affect these facets of human development.

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Psychology, Music Training, Self Esteem, Emotional Intelligence, Education

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Creative Commons Attribution 4.0 and The Open Definition

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Calnexin is an ER resident protein with calcium binding ability. It has known functions in glycoprotein folding and maturation. Cumulative evidences indicate the implication of calnexin in apoptosis induced by ER stress. Calnexin gene silencing in lung cancer cell line was shown to decrease cancer cell survival leading to effective chemotherapy. MAR binding protein SMAR1, established to have both tumor suppressor as well as immuno-modulatory functions. We speculated that apart from its tumor suppressor function, SMAR1 might also be involved in immunosurveillance of cancer cells. Earlier results depicted that SMAR1 increases the enrichment of both GATA2 and HDAC1 at calnexin promoter that they might interact with each other and form a repressor complex. However, no reports are available showing its interaction with HDAC1. SMAR1 is known to interact with HDAC1, but its interaction with GATA2 is unknown. We hypothesize that SMAR1 might form a triple complex with GATA2 and HDAC1 resulting in deacetylation of GATA2. We then checked the interaction between SMAR1, GATA2 and HDAC1. GATA2 Acts as an Activator of Calnexin in the Absence of SMAR1. GATA2 is known to act as an activator under acetylated condition, this acetylation is generally carried out by p300, an important member of HAT family of proteins. We try to establish that SMAR1 forms a triple complex with GATA2 and HDAC1. In the presence of SMAR1, there is reduction in acetylation of GATA2. So, we further want to check how SMAR1 and HDAC1 helps in the weak acetylation of GATA2.

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GATA2, HDAC1, SMAR1

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Creative Commons Attribution 4.0 and The Open Definition

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The description, characterization and quantisation of the identified and unidentified impurities present in new drug substances is known as impurity profile. Impurity is defined as any substance coexisting with the original drug, such as starting material or intermediates or that is formed, due to any side reactions. Impurity can be of three types: Impurities closely related to the product and coming from the chemical or from the biosynthetic route itself, Impurities formed due to spontaneous decomposition of the drug during the storage or on exposure to extreme conditions, or the precursors which may be present in the final product as impurities. The suggested structures of the impurities can be synthesized and will provide the final evidence for their structures, previously determined by spectroscopic methods. Therefore it is essential to know the structure of these impurities in the bulk drug in order to alter the reaction condition and to reduce the quantity of impurity to an acceptable level. Isolation, identification and quantification of impurities help us in various ways, to obtain a pure substance with less toxicity and, safety in drug therapy.

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cefotaxime ofheavy multi-component diacetylatedparacetamol

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Hospital wastes pose a significant impact on health and environment. It spred the environmental polution and affect the health of human and animal. So study of bio-medical Weste is very important.

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Creative Commons Attribution 4.0 and The Open Definition

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Immunization pathological waste microbiology culture

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Creative Commons Attribution 4.0 and The Open Definition