Volume 13 | Issue 5 |

 Abstract

Recent advancements in biomimetic materials have significantly impacted the field of ophthalmology, particularly in the development of next-generation vision correction devices. This study focuses on the creation of an innovative contact lens composed of corneal tissue-derived biomaterials, aiming to enhance both functionality and compatibility with the ocular environment. Conventional contact lenses, typically fabricated from hydrogel or silicone hydrogel, are often associated with drawbacks such as limited oxygen transmission, discomfort, and potential long-term corneal damage. To overcome these issues, this research utilizes decellularized corneal tissue combined with engineered extracellular matrix (ECM) elements to construct a contact lens that closely replicates the natural structure and function of the human cornea.The manufacturing process involves several stages, including decellularization of corneal tissue, ECM hydrogel development, and polymeric support for enhanced mechanical strength. Biocompatibility was assessed in vitro using human corneal epithelial cells, showing improved cell adherence and growth when compared to standard lens substrates. Optical transparency and oxygen permeability evaluations revealed that the tissue-based lens meets, and in some aspects surpasses, the performance benchmarks required for clinical use. Additionally, the lens exhibited excellent moisture retention and durability during simulated extended wear tests.This approach offers a promising alternative for individuals with ocular sensitivities or corneal pathologies, as well as those interested in regenerative solutions for vision correction. Future work will focus on in vivo validation and patient-specific customization. Overall, this development represents a significant step forward in the integration of tissue engineering with vision care technologies.

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 Keywords

Corneal-derived biomaterials, bioengineered contact lens, vision restoration, extracellular matrix (ECM), decellularized tissue, ocular biocompatibility, optical transparency, regenerative vision therapy, tissue-engineered ophthalmic device, corneal mimetic materials

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Abstract The current study does a webometric analysis on four autonomous institutes in the Goa state. The principal aim is to appraise and analyse their online presence using a range of webometric. These consist of connected pages, domain names, page authority, and the quantity of web pages. Other important online impact metrics that are computed by the study include Self-Link Web Impact Factor (SLWIF), the External Link online Impact Factor (ELWIF), and the Revised Web Impact Factor (RWIF) also Google page rank. Websites are an essential digital interface for organizations, representing their identity, reach, and resources. They serve as an important information source for stakeholders and reflect institutional functioning. To gain a better knowledge of the chosen institutions' digital footprint and efficacy in online communication, this study offers a webometric analysis and their review of the website indicates that the study is the most recent and distinct. There are few webometric studies on the autonomous institutions of Goa.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Autonomous institutions in Goa,Webometrics, Linked Domain, Link Analysis, Self-Link, External Link, Web Impact Factor.

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Ayurveda is the most ancient system of medicine. Pandu Roga is one of the diseases mentioned in Ayurveda characterised by changes in skin colour to white[Shweta],yellowish[Peeta],greenish[Harita].etc. Most of the Acharyas have described 5 types of Pandu Roga i .e Vatika, Paitika, Kaphaja, Tridoshaja, Mridbhakshanajanya Pandu. Acharya Charaka, A. Vagbhata & Madhava Nidana have mentioned about Mridbhakshanajanya (soil eating)Pandu. At least one of the Doshas of the individual who has a habit of eating soil gets aggravated, due to dry nature of the soil, it makes the tissues of the body dry. Pica is the eating of, or craving to eat things that are not food. Mridbhanakshanjanya Pandu is a condition that alters gut health, weakens digestion, and predisposes individuals to Krimi. In Krimi Chikitsa through Nidana Parivarjana[elimination of causative factors],Prakriti Vighata [modification of favorable conditions for Krimi] and Apakarshana[expulsion of parasites].Understanding this relationship can help formulate effective Ayurvedic interventions for better management.

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 Keywords

Pandu Roga, Krimi, Doshas,Pica ,Mridbhakshanjanya Pandu

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Pulsed drug delivery systems (PDDS) are essentially time-controlled drug delivery devices in which the mechanism controls the lag time independently of external factors such as intestinal motility, pH, enzymes, etc. A pulsatile drug release, in which the drug is delivered rapidly after a predefined lag period, may be advantageous for a variety of drugs or therapies. Drugs are often released either immediately or gradually. Pulsatile drug release systems, however, have drawn more attention in recent years. Many medications or treatments may benefit from a pulsatile drug release, in which the drug is delivered quickly following a predetermined lag time. There are two types of pulse release systems: single-pulse and multiple-pulse. The family of single-pulse systems known as rupturable dose forms is widely used. One such method is pulsatile medication delivery, which promises to help patients with chronic conditions including arthritis, asthma, and hypertension by administering drugs at the appropriate times, locations, and dosages. Systems for pulsatile medication delivery may lead to major advancements in the treatment of several illnesses. Technologies including Pulsincap, Diffucaps, CODAS, OROS, and PULSY Saremarketed. The press coating process is a simple and unique technology that yields tablets with a programmable lag phase and a quick, or rate-controlled, drug release after ingestion, among its numerous advantages. These tablets may be made without the need of specialized coating equipment or solvent. When selecting the best chronopharmaceutical technology, consideration should be given to both production ease and cost-effectiveness.

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 Keywords

PDDS;Pulsatile Drug Delivery System, Chronobiology, Sustained Release, Lag Time, Circadian Rhythms, Chronotropic system, Osmosis.

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

The growing urbanization and city population expansion have resulted in an immense rise in vehicle congestion, necessitating the need for advanced and responsive traffic control systems. The current research offers an advanced, real-time traffic management system implemented using Raspberry Pi and the YOLOv5 object detection engine. The system takes a real-time video feed as input and detects and classifies various vehicle classes, dynamically adjusting traffic signal timings based on vehicle density in particular lanes. One notable feature of the system is the detection of emergency vehicles--ambulances and fire trucks--and overriding regular signal functioning to give them constant right-of-way. The implementation is highly accurate, with a mean Average Precision (mAP@0.5) of 0.865, detection accuracy of 97% for ambulances, and a detection accuracy of 94% for fire trucks. Additionally, an easy-to-use web interface implemented using Flask allows real-time monitoring and control. This smart system significantly improves urban traffic flow and allows earlier emergency response, and it is a promising scalable part of smart city infrastructure.

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 Keywords

Artificial Intelligence, Computer Vision, Emergency Vehicle Detection, Intelligent Traffic System, Smart City, Traffic Management, YOLOv5

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Project Based Learning (PBL) is a teaching method that encourages students to solve real-world problems. This work focuses on project-based learning and culminates in Indian universities as teachers find ways to make learning meaningful and engaging for boys and girls. Project-based learning begins with a problem or task. Practical and realistic issues or problems that affect students' knowledge and development levels form the -basis of project-based learning teaching. Teachers teach students by asking questions, finding information, and looking at information. Encourages important skills such as teamwork, independent work, self-evaluation, time management, study, or oral and written communication. There are many benefits of using PBL in Indian universities. First, PBL can help students develop 21st-century skills such as problem-solving, critical thinking, and collaboration. These skills are essential to being successful at work and in life. Second, VET can help students learn better by engaging in active learning.

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 Keywords

Instructional approach, group work, autonomous learning, self-assessment skills, time planning, problem-solving, critical thinking, collaboration, etc.

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Sentiment analysis, also known as opinion mining, is a natural language processing (NLP) technique used to determine the emotional tone behind textual data. This project focuses on implementing sentiment analysis on product reviews to automatically classify customer feedback as positive, negative, or neutral. By leveraging machine learning algorithms and text processing techniques, the system analyzes user-generated content from e-commerce platforms to extract valuable insights into customer satisfaction. The goal is to assist businesses in understanding consumer sentiment at scale, enhancing product development, marketing strategies, and customer experience. Experimental results demonstrate that the model effectively captures sentiment polarity with high accuracy, showcasing its potential as a decision-support tool in online retail.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

SentimentAnalysis, OpinionMining, Product review analysis, Natural language processing(NLP),Customer Feedback analysis.

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Indian democracy is facing the challenge of deepening its democratic form of governance at the local level but presently our civil society, intellectuals and political class do not realize it. The 73rd and 74th constitutional amendments which were initiated with the purpose of empowering the local governance but this democratic revolution has been hijacked by the ruling elites governing the different states with the help of district administrative setup. Panchayats and Municipal governments are not really empowered to legislate and administer upon the subjects devolved to them by the constitutional amendments because the state are not willing to part with their powers and vested interests.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Failure of Genuine Democratic Decentralization & Question of Substantive Democracy in India

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Setting up a secured web server environment on Arch Linux is a multifaceted process that entails configuring a lightweight and efficient server with robust security mechanisms. Arch Linux, known for its simplicity and flexibility, provides the ideal platform for deploying tailored web services. This guide details the essential components of creating a secure web server, focusing on software installation, configuration, access controls, and implementing best security practices. The tools involved include OpenSSL for TLS/SSL implementation, UFW or iptables for firewall configuration, and Fail2Ban for intrusion prevention. Existing systems often lack comprehensive security measures, leaving them vulnerable to various cyber threats. The proposed system focuses on creating a highly secure web server environment on Arch Linux by implementing multiple layers of security. This includes the latest encryption protocols, stringent firewall rules, and proactive intrusion prevention techniques, significantly enhancing the server's resilience against attacks.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Arch Linux, secured web server, Nginx, Apache, SSL/TLS, Let's Encrypt, firewall, UFW, iptables, intrusion detection systems (IDS)

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

This project proposes a Neural Intrusion Detection System (Neural IDS) that leverages deep learning techniques to detect and classify cybersecurity threats in real time. By applying artificial neural networks to analyze network traffic patterns, the system achieves higher detection rates and reduced false positives compared to traditional signature-based systems. The model is trained on benchmark datasets, learning complex attack signatures and behavioral anomalies. The integration of intelligent threat detection into network security infrastructures ensures proactive defense, adaptability to novel threats, and automated response mechanisms..

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Keywords-- Intrusion Detection System, Cybersecurity, Deep Learning, Neural Networks, Threat Detection, Anomaly Detection

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Creative Commons Attribution 4.0 and The Open Definition