Volume 8 | Issue 12 |

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Jaivik Krishi Our Jaivik Khadon Ka Mrida Ke Bhautik, Rasayanik Avm Jaivik Gunon Par Prabhav Tatha Jaivik Khad Prabandhan

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Jaivik Krishi Our Jaivik Khadon Ka Mrida Ke Bhautik, Rasayanik Avm Jaivik Gunon Par Prabhav Tatha Jaivik Khad Prabandhan

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Abstract Molecular hybridization of nucleic acids is the process in which two single-stranded nucleic acid molecules with complementary base sequences form a double-stranded nucleic acid molecule. Nucleic acid hybridization technology is a fundamental tool in molecular biology, and has been applied in various fields such as detection of gene expression, screening specific clone from cDNA or genomic library, determining the location of a gene in chromosome and diagnosis of diseases. Cage like property for eg graphene or glue like bio material from spider or even polymer can bind rapid growth of cell for its binding nature at micro level or can trap bacterial or viral growth by trapping within Net like structure. The idea of Quantum Dots may be implied to identify such net as drug to separate from diseases infected Zone. Sometime electrification or by application of Radioactivity through this net may reduce harmful diseases spreading. Molecular hybridization a useful tool in the design, trapping of new generation drug prototypes using the sequencing of Nucleic acids for a particular patient. Molecular hybridization is a new concept in drug design and development based on the combination of pharmacophoric moieties of different bioactive substances to produce a new hybrid compound with improved affinity and efficacy, when compared to the parent drugs. Additionally, this strategy can result in compounds presenting modified selectivity profile, different and/or dual modes of action and reduced undesired side effects. So, in this paper, we described several examples of different strategies for drug design, discovery and pharmaco modulation focused on new innovative hybrid compounds presenting analgesic, anti-inflammatory, platelet anti-aggregating, anti-infectious, anticancer, cardio- and neuroactive properties. By this molecular hybridization concept in the field of genetic engineering and as well as molecular biology, formation of a partially or wholly complementary nucleic acid duplex as association of single strands, usually between DNA and RNA strands (previously associated or un associated DNA , RNA strands.). These are used to detect an isolated specific genetically initiated sequences as measured sequencing homology, or define other characteristics of one or both strands. If we can detect the particular cause of critical disease like Parkinson, Cancer or AIDS for a particular patient. We can synthesis the new drug design for that patient to treat them for complete cure in this molecular hybridisation concept. So this is a new generation concept for developing drug as well as the cause of the particular diseases for a particular patient. Not only that by fusing more than one drugs structure components by Molecular hybridisation concept we can make a single drug for a patient with multiple affected diseases using computer simulation more modern method in the field of medicinal chemistry. The idea will show us to find the way of sustainable health and immortality in future.

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Keywords: Molecular hybridization, Drug design, Hybrid compounds, Pharmacophoric group combination, DNA and RNA Sequencing.

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Sanskrit literature is not only rich in the grammatical composition and romantic expression but also in knowledge about environment, its destruction and the need for its protection which come up in many contexts every now and then whenever any attempt is made to study this literature. Starting from the Vedic age till now it carries a number of appearances in the writings of scholars. This need to be explored in detail as the vast size and span of it leaves enough scope for researchers to dig up those sources of knowledge. In this paper different sources of knowledge are studied to find out the concern and knowledge on environment and its protection. It includes all those valuable sources to do maximum justice to the objective of the paper.

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environmental concern, Sanskrit, text, Vedas, puranas

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Dalits have been facing discrimination and oppression at the hands of the upper-caste since centuries in both rural and urban spaces. However, in rural spaces it is even more rampant and aggressive as compared to in the urban spaces. With the development and expansion of modern cities in India in the early 1900s, the cities provided space for many Dalit families to put behind their identities as merely Dalits and acquire the respect that every human deserves. This paper attempts to read Narendra Jadhav�s Untouchables: My Family�s Triumphant Journey Out of the Caste System in Modern India, a biographical account of his father�s life to understand and explore caste discrimination and its transformation across generations in both rural and urban settings.

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biography, caste, Dalit, discrimination, emancipation, rural, urban

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Current Liquidity position of UGVCL Company

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Liquidity analysis of UGVCL COMPANY

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This paper is concerned with the construction of the composite development index for all districts taking agricultural, industrial and infrastructural indicators to assess the relative position and direction of change during the period of study. In the first part, indicators found significant for construction of Composite Index for overall development are discussed. Composite Indices for overall development for 1995-96 and 2007-08 were constructed and compared in the second part. Last part of this paper discusses the pattern of change in the era of economic reforms in terms of impact on different levels of development between districts and the pace of development in relatively under-developed districts. An attempt has been made to trace out correlates of development

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Era of Economic Reforms,Composite Index,Correlates of Development

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Agmatine is the product of arginine decarboxylation and can be hydrolyzed by agmatinase to putrescine, the precursor for biosynthesis of higher polyamines, spermidine, and spermine. Besides being an intermediate in polyamine metabolism, recent findings indicate that agmatine may play important regulatory roles in mammals. Agmatine, 4-aminobutyl guanidine, has recently been found in various mammalian organs and is thought to act as a neurotransmitter or neuromodulatory agent. The present study is to do a review on agmatine and its synthesized analogues till now for agmatinase inhibitory action. Agmatinase is a binuclear manganese metalloenzyme and belongs to the ureohydrolase superfamily that includes arginase, formiminoglutamase, and proclavaminate amidinohydrolase. Compared with a wealth of structural information available for arginases, no three dimensional structure of agmatinase has been reported. Agmatinase is an enzyme which blocks the mammalian agmatine which is ultimately responsible for the agmatine degradation in the body. Agmatinase is an enzyme which regulates the half life of agmatine in the brain. Hence a selective inhibitor of brain agmatinase is required. Several derivatives of agmatine are synthesized previously for agmatinase inhibitory activity but none of them showed selective inhibition. PZC (Piperazinecarboxamidine) is a derivative of agmatine or guanidine is expected to show selective inhibition of human agmatinase. A detailed review is carried out in order to understand the agmatinase inhibitor.

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Agmatinase, Neurotransmitter, Neuromudulator, Guanidine, Piperazinecarboxamidine, Putrescine, arginase, Catecholamines, Nitric oxide synthase (NOS), N-methyl, D-aspartate (NMDA)

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The current scenario of environmental degradation is enforcing every individual to focus on sustainability. Green baking aims is to take a proactive action towards environmental protection. Banking industry have a vital impact on society as this can impact our day to day life. This study will focus on the impact of adopting green banking on all the stakeholders like customer, employee and organization itself. After facing many environmental disasters every individual wants to contribute to changing scenarios. Every organization runs its business for profit-making, and hence it is necessary for an organization to know its profit before adopting any changes for sustainability. This study is a literature review of green banking and its benefit for every stakeholder of banks. Researcher has considered more than 50 studies for this study. The objectives of this paper are to study practices of green banking and its impact on customer satisfaction. After find impact on customer researcher again find impact on employee of bank. In last researcher find overall impact on organization.

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Environment, Sustainability, Green Banking, Customer, Employee, Organization.

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With the exponentially rising affluent middle-class income category urban Indians, the lifestyle of the people has seen a significant change since the last decade. The role of brands tends to play a much influencing role in today�s generation especially for this category of people to suit themselves with the urban social life. The people belonging to Generation Z are witnessed to be a large chunk of consumers in India who behave extremely different from generation X and Y thereby calling in for a pressing need to analyse their behaviour across genders. The present study aims to evaluate the difference in footwear purchasing behaviour of generation Z Indians across males and females and also check the role of sales promotion when it comes to purchasing of branded footwear from branded outlets. The data is collected from 385 respondents from different parts of the country and the difference in behaviour is further analyzed with the help of Levene�s test of homogeneity, independent t-test and Cohen�s d. The study interprets certain distinct findings like women being more involved in short term buying behaviour as in comparison to men, the stronger influence of sales promotion over tools upon women than men and such others.

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Generation Z, Sales Promotion, Footwear, Retail, India.

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A.K. Ramanujan�s colleagues in the university of Chicago, Susanne and Lloyd Rudolph, writes about the most distinguishing characteristics of his personality is his �humanity� and �modesty�. As a man and a writer, he avoided loud and big gestures. He was preoccupied with the small, the insignificant and the everyday experiences. Ramanujan has descended from an orthodox Brahmin lineage and had firsthand knowledge about the hypocrisies that had polluted such an ancient and indigenous religion as the Sanatan Dharma or Hinduism. So as a poet, linguist, folklorist, translator and literary theorist, Ramanujan�s lifelong endeavor was to make a more humane society and his poetry is a rich treasure-trove of his humanistic concerns.

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A. K. Ramanujan, Humanism, Indian Society, Modernism.

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