Volume 13 | Issue 12 |

 Abstract

o Nutraceuticals are the nourishing components (hybrid of nutrition and pharmaceuticals) that are biologically active and possess capability for maintaining optimal health and benefits. o These products play a significant role in human health care and its endurance, most importantly for the future therapeutic development. o Nutraceuticals are globally growing in the field of services such as health care promotion, reduction, etc. o Nutraceuticals have been used not only for nutrition but also as a support therapy for the prevention and treatment of various diseases, such as to reduce side effects of cancer chemotherapy and radiotherapy. o Diverse novel nanoformulation approaches tend to overcome challenges involved in formulation development of nutraceuticals. o Nanotechnology also leads to the generation of micronized dietary products and other nutraceutical supplements with improved health benefits. o Nutraceuticals have been used not only for nutrition but also as a support therapy for the prevention and treatment of various diseases, such as to reduce side effects of cancer chemotherapy and radiotherapy. o In this review article, the latest key findings (clinical studies) on nutraceuticals that show the therapeutic action of nutraceutical's bioactive molecules on various diseases have also been discussed.

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cardiovascular diseases, interactions, nutrition, prevention, therapeutics

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Ginger the rhizome of Zingiber Officinalis ,one of the most widely used species of the ginger family is a common condiment for various food and beverages ginger has along history of medicinal use dating back 2500 years Ginger has been traditionally used from time immemorial for varied human ailment in different part of the globe ,to aid digestion and treat stomach upset ,diarrhoea ,and nausea. Some pungent constituent present in ginger and other zingiberaceous plant have potent antioxidant and anti-inflammatory activities ,and some of them exhibit cancer preventive activity in experimental carcinogenesis. The anticancer properties of ginger are attribution to the presence of certain pungent vallionidsviz {6} -paradol as well as other constituent like shogaols,zingerone etc .. A number of mechanism that may be involved in the chemopreventive effect of ginger and its component have been reported from the laboratory studies in a wide range of experimental.

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PHYTOMEDICINE INCLUDING CHARACTERICFETUR OF GINGER

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"One Nation, One Election" (ONOE) in India advocates concurrent elections for the centre and the State Legislative Assemblies. In the early decades following independence, concurrent elections were employed; however, many early dissolutions of state assemblies and intermittent periods of federal rule have led to a staggered electoral schedule. This continuous election cycle imposes significant financial, administrative, and governance restrictions. These risks include the regular application of the MCC, the diversion of society employees and security personnel, and the disruption of policy implementation. With the objectives of boosting voter turnout, cutting public spending, enhancing policy coherence, and streamlining election administration, ONOE is proposed as a solution to these problems. Despite its promises of better governance and economic efficiency, the initiative's execution faces substantial challenges, including as constitutional amendments, federal concerns, and logistical constraints. Aligning national and state elections has the potential to obscure regional issues, marginalize small parties, and affect India's federal structure. However, with enough planning, ONOE can reduce election fatigue, optimize administrative and financial resources, and foster democratic functioning by allowing governments to focus on long-term policy objectives rather than ongoing campaigning. This article provides an institutional analysis of ONOE, examining its history, benefits, implementation challenges, and implications for India's democratic governance.

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ONOE, Concurrent Elections, MCC, Electoral Cost, Democratic Accountability, Voter turnout.

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o Moisturizers are one of the most widely used preparations in cosmetics and have been extensively used to soften the skin for consumers. Moisturizers work effectively in combating dry skin which may cause pain, tightness, itch, stinging, and/or tingling. o Moisturizers bridge the gap between medicine and consumer goods by being used to make the skin more beautiful and healthy. In the future, in moisturizer therapy, the capacity to adapt specific agents to specific dermatological demands will be crucial. Cosmetically, moisturizers make the skin smooth by the mechanism of increasing the water content in the stratum corneum, hence exerting its most vital action, which is moisturizing action and maintaining a normal skin pH. o The aim of this review is to evaluate published studies on the history, ingredients, preparation processes, characteristics, uses, and applications of moisturizers.Suitable methods of preparation of creams, their classification based on their function, their advantages and disadvantages, characteristics and the various types of creams, ingredients used in the formulation of creams and their various evaluation parameters.

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COSMECEUTICALS OF MOISTURIZER CREAM

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Inflammation is a fundamental biological response to injury, infection, or physiological stress. However, chronic inflammation is associated with a wide range of diseases, including rheumatoid arthritis, cardiovascular disease, diabetes mellitus, neurodegenerative disorders, and cancer. Phytomedicine, which relies on plant-derived bioactive compounds, has gained global recognition as a potential complementary or alternative approach for managing inflammation. This review provides a comprehensive overview of the anti-inflammatory activities of major phytochemicals, their mechanisms of action, pharmacological relevance, and potential therapeutic applications. The review also highlights challenges and future directions in translating phytomedicine-based therapies into clinical practice.

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Phytomedicine in Inflammatory Disorders: A Comprehensive Review of Anti-Inflammatory Phytochemicals

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The Neem (Azadirachta indica) has a vital role in various problems associated with human health. The chemical constituents present in the neem plant make it a doctor tree due to its wide scope in biological activities associated with it, and has become a global context today. Neem (Azadirachta indica) is considered harmless to humans, animals, birds, beneficial insects and earthworms, and has been approved by the US Environmental Protection Agency for use on food crops. Azadirachtin and other active ingredients in the neem seed have insecticidal properties that are effective against a broad spectrum of insects, many mites and nematodes, and even snails and fungi, and do not seem to generate resistance in the pests they affect. Nowadays, neem and its extracts are used in numerous herbal medicines and cosmetics. What's more, even neem contraceptives are available in the market this days. Neem extract which have Nimbinin, nimbandiol as active constituents, alcoholic extract of the leaves was found to possess a significant blood sugar lowering effect, which are very useful against diabetes. Neem is used in Dermatitis Eczema, Acne, Bacterial/Fungal infections and other skin disorders. It has demonstrated its effectiveness as a powerful antibiotic. Neem also has shown antiviral, anti- fungal and anti-bacterial properties. It helps support a strong immune system and is used in cases of inflammatory skin conditions. Neem has been extensively used in Ayurveda, Unani and Homoeopathic medicine and has become a centre of attraction of modern medicine. Hence, the article is aims to utilize the medicinal properties of whole neem plant in various disorders of mankind.

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azadirachta indica, anti-viral, anti-fungal, and diabetic.

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My Research Paper is about the Covid Pandemic affects the mental and the overall well being if employees working in different sectors.

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Pandemic,Mental Health , Well being , Employees , industrial Psychology

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2025, CSR is no longer a peripheral corporate function but a core legal obligation. This paper explores the transition from "soft law" to "hard law," focusing on mandatory spending, ESG (Environmental, Social, and Governance) disclosure mandates, and the rising tide of climate and social litigation.

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These terms relate to the laws that force companies to act or report on their social impact. Mandatory Disclosure: Legal requirement for companies to report non-financial data. Section 135 (Companies Act 2013): Specifically for India; the landmark law mandating a 2% spend on CSR.

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Background: The posterior superior alveolar artery (PSAA), a vital branch of the maxillary artery, supplies the lateral maxillary sinus wall and posterior maxilla. Anatomical variations in the PSAA are clinically significant, particularly during sinus lift procedures, implant placement, and maxillofacial surgeries, where inadvertent arterial injury may lead to hemorrhage and compromised surgical outcomes. Cone-beam computed tomography (CBCT) provides accurate three-dimensional visualization of maxillary sinus anatomy and is the preferred modality for pre-surgical planning. Understanding the PSAA's position relative to the sinus floor and alveolar crest in different dentition states is essential for improving surgical safety. Aim: To assess the anatomical location and distances of the intraosseous PSAA from the floor of the maxillary sinus and the alveolar crest in dentulous and partially edentulous patients, and to evaluate variations based on gender using CBCT. Materials and Methods: A cross-sectional retrospective analysis of 188 CBCT scans of patients aged 18-75 years was conducted. Scans were divided into two groups: dentulous (n = 94) and partially edentulous (n = 94). The PSAA was identified on coronal and sagittal CBCT sections, and linear measurements were made from its inferior border to (1) the maxillary sinus floor and (2) the alveolar crest in the first or second molar region. Scans with artifacts, pathology, impacted teeth, or prior surgical changes were excluded. Data were analyzed using SPSS version 22.0, with a significance level of p <= 0.05. Results: The mean distance of the PSAA to the sinus floor was 9.98 mm in dentulous patients and 9.67 mm in partially edentulous patients, showing no statistically significant difference (p = 0.450). The mean distance of the PSAA to the alveolar crest was 17.53 mm in dentulous patients and 15.51 mm in partially edentulous patients, indicating a statistically significant reduction in partially edentulous individuals (p = 0.001). Gender analysis revealed: o Dentulous group: No significant gender differences for PSAA distance to the sinus floor or alveolar crest (p > 0.05). o Partially edentulous group: A significant gender difference was found in PSAA distance to the sinus floor (greater in males; p = 0.022), while the distance to the alveolar crest showed no significant difference (p = 0.143). Conclusion: The PSAA's position relative to the sinus floor remains comparable between dentulous and partially edentulous patients; however, its distance to the alveolar crest is significantly reduced in partially edentulous individuals due to post-extraction alveolar bone resorption. Gender differences are minimal but become significant in partially edentulous patients regarding sinus floor measurements. CBCT provides high accuracy for PSAA localization and plays an essential role in pre-operative planning for implant placement and sinus augmentation procedures. This study offers valuable baseline data to enhance surgical safety and minimize vascular complications in the posterior maxilla.

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 Keywords

PSAA, sinus floor, alveolar crest, dentition status, CBCT

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Creative Commons Attribution 4.0 and The Open Definition

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Public Debt, Inflation, Government Expenditure, Economic Growth, ARMAX Model, India

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