Volume 13 | Issue 12 |

 Abstract

Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disorder characterized by progressive inflammation of synovial joints, leading to pain, stiffness, swelling, and ultimately irreversible joint destruction if not managed appropriately. Over the past decades, RA has been recognized not only as a joint-specific disease but also as a systemic condition that affects various organs, including the cardiovascular, pulmonary, and hematological systems. The pathogenesis of RA is exceptionally complex, involving a multifactorial interaction of genetic predisposition, environmental triggers, immune dysregulation, and aberrant cellular signaling pathways. The immune system, which normally protects the body from pathogens, mistakenly identifies components of the synovial membrane as foreign, triggering a cascade of inflammatory reactions. This autoimmune attack is mediated by a combination of T cells, B cells, macrophages, and fibroblast-like synoviocytes (FLS), all of which participate in driving chronic inflammation. Cytokines such as tumor necrosis factor-alpha (TNF-?), interleukin-1 (IL-1), and interleukin-6 (IL-6) are central mediators of RA pathogenesis. These cytokines amplify inflammatory responses, recruit additional immune cells to the synovial tissue, and stimulate enzymes that degrade cartilage and bone. The synovium, which is normally a thin, delicate membrane, becomes thickened and hyperplastic, forming an invasive tissue known as pannus. This pannus aggressively expands across joint surfaces, eroding cartilage and bone through the activation of osteoclasts and matrix metalloproteinases. Over time, this destruction leads to joint deformity, functional impairment, and significant disability.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

RheumatoidArthritis, Hyperplasia, JointDestruction

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Artificial Intelligence and Automation are dramatically reshaping the activities of a world of business and work. While greater productivity from these systems is reflected on one side, job and skill mismatch is seen on the flip side. This investigates the ways in which AI and automation influence labor dynamics in similar industries and how reskilling and upskilling mechanisms can assist workers. Primary data collection for this research took place using an online survey among workers in the manufacturing, healthcare, and service industries as well as human resource practitioners and industry experts, making use of quantitative methods for data analysis. The statistical content analysis was employed making use of SPSS software encompassing test for reliability, demographic analysis, ANOVA, and regression models. The ANOVA assessed sector-level differences in job creation, skill transitions, employee adaptation, employee productivity, respectively, while regression tests assessed how things like support for employees and in training program effectiveness influenced participation of employees. The conclusions drawn offer encouraging news about the changing shape of labor markets, increasing productivity, and labor market polarization and the role that AI and Automation will play in this. Strong reskilling and organizational support programs are huge incentives in making the most out of these changes.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Artificial Intelligence (AI), Automation, Workforce Transformation, Digital Economy, Reskilling and Upskilling

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Quick commerce (Q-commerce) has rapidly emerged as a transformative retail and logistics model, emphasizing ultra-fast delivery of essential goods within a short time frame, typically between 10 to 30 minutes. Driven by digitalization, urbanization, and changing consumer lifestyles, Q-commerce platforms have significantly reshaped urban logistics systems. The expansion of quick commerce has increased the demand for hyperlocal warehouses, commonly known as dark stores, and has intensified last-mile delivery operations supported by advanced technology-based logistics solutions. This study aims to analyse the rise of quick commerce and examine its impact on urban logistics with reference to delivery efficiency, logistics cost, traffic congestion, and environmental implications. The research is based on secondary data collected from academic journals, industry reports, and market studies. The findings reveal that while quick commerce enhances customer convenience and delivery speed, it also places substantial pressure on urban infrastructure, increases operational costs, and raises sustainability concerns. The study suggests strategic and sustainable measures to improve efficiency in urban logistics systems.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Quick commerce, Urban logistics, Last-mile delivery, Dark stores, Supply chain

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Nanotechnology is the science that deals with the process that occurs at a molecular level and nano length scale size and it has developed as a great field in medicine. Nano refers to particle size range 1-1000 nm. Nanotechnology is the part of Nanosuspension. They are important carriers in developing novel drug formulations. Many drugs have solubility as a crucial factor for drug effectiveness and independence of route of administration. The nanosuspension contains a sub-micron colloidal dispersion active pharmaceutical ingredients. Particles in the liquid phase are stabilized by surfactants. The production of drugs in the form of nanosuspension has been advanced for drug delivery systems in the form of oral formulation and of non-oral administration, nanosuspension proved to be a better and attractive alternative approach compared to others. conventional formulations. This review narrates the pharmaceutical nanosuspension formulation, preparation, characterization, and pharmaceutical application in drug delivery as well as marketed product

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Nanosuspension, drug delivery, colloid

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

The Schedule tribes and others traditional forest dwellers (recognition of forest rights) act, 2006, popularly known as FRA, aims to "undo historical injustice'' to forest dependent communities. Odisha being one of the tribal dominated state in the country becomes an important state to assess the implementation of the act. Data reveals that the implementation of this act is of relative success in compare to its potential. This article looks deep into the structural and institutional hindrances affecting its implementation in the state. This work also looks into the Adivasis-state relations from pre-colonial to present time.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Keyword: Community forest rights, Adivasis, state, implementation, neo-liberal, Odisha.

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Creative Commons Attribution 4.0 and The Open Definition

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- Accessing organizational data typically requires SQL knowledge, leaving non-technical staff dependent on IT. Our research presents an AI/NLP system that creates a natural language query interface. This allows users to access databases (PostgreSQL, MySQL, CSV) using simple commands. Using LlamaIndex and Gemini, it identifies intent, constructs SQL, and visualizes results. This framework improves accessibility and reduces IT dependency, filling the NL2SQL gap with an open-source, conversational solution for human-accessible information systems.

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 Keywords

Natural Language Processing (NLP), Artificial Intelligence (AI), Natural Language to SQL (NL2SQL), Data Query System, LlamaIndex, Google Gemini, FastAPI, Human-Accessible Information Systems)

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Creative Commons Attribution 4.0 and The Open Definition

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The growing integration of Artificial Intelligence (AI) in Human Resource Management has significantly reshaped recruitment and selection practices. Organizations are increasingly utilizing AI-enabled video interview platforms, including Hire Vue and Tal view, to support structured candidate assessment and informed hiring decisions. This study investigates the role of AI-based video interviewing systems in influencing hiring outcomes, with a focus on recruitment efficiency, objectivity in evaluation, candidate experience, and recruiter productivity. The research adopts a secondary data approach, drawing evidence from scholarly publications, industry analyses, and documented organizational practices. The findings reveal that AI-driven video interviews enable faster screening processes, promote uniform evaluation standards, and enhance data-supported decision-making. Nevertheless, issues related to algorithmic fairness, ethical responsibility, and system transparency remain key concerns. The study concludes that AI-powered video interview platforms can effectively support hiring decisions when complemented by human judgment and strong ethical governance mechanisms.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Artificial Intelligence in HRM, AI-Enabled Video Interviewing, Recruitment Decision Processes, Ethical Hiring Practices, Candidate Evaluation Analytics

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Background: Minor accidents such as falls, burns, cuts and poisoning are common among children and can lead to significant morbidity. Mothers play a vital role in preventing such accidents through appropriate knowledge and safety practices. Objectives: To assess the knowledge regarding prevention of minor accidents in children among mothers and to determine the association between knowledge levels and selected demographic variables. Methods: A quantitative research approach with a non-experimental descriptive research design was adopted. The study was conducted among 60 mothers residing in Adgaon village, Nashik, using purposive sampling technique. Data were collected using a structured knowledge questionnaire on prevention of minor accidents in children. Results: The findings revealed that 62% of mothers had good knowledge, 25% had average knowledge, and 13% had poor knowledge regarding prevention of minor accidents in children. Chi-square analysis showed no statistically significant association between knowledge levels and selected demographic variables. Conclusion: The study concluded that although most mothers had adequate knowledge regarding prevention of minor accidents in children, continuous health education is essential to further strengthen preventive practices and ensure child safety.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Minor accidents, Children, Mothers, Accident prevention, Community health nursing.

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Women safety has become a major concern in today's society due to the increasing number of harassment, assault, and emergency situations faced by women. With the rapid growth of smartphone technology, mobile applications can play an important role in providing immediate help and support during dangerous situations. This project presents a Women Safety Application designed to ensure the safety and security of women by using smart mobile technologies. The proposed application provides features such as one-tap emergency alert, real-time location tracking, SMS and call alerts to emergency contacts, and panic button activation.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Women Safety, Women Safety App

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Education plays a crucial role in shaping the intellectual, moral, and social values of individuals. Nationalism, universalism, and secularism are three fundamental ideals that guide the development of a democratic and harmonious society. Nationalism fosters unity and a sense of identity, universalism promotes global brotherhood, and secularism ensures equality and respect for all religions. In a pluralistic country like India, education serves as a powerful medium to inculcate these values among students. This paper attempts to analyse the concepts of nationalism, universalism, and secularism and examine their inter-relationship with education. It also highlights the role of education in promoting unity, peace, tolerance, democratic values, and global citizenship.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Keywords: Nationalism, Universalism, Secularism, Education, Democratic Values

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Creative Commons Attribution 4.0 and The Open Definition