Volume 10 | Issue 11 |

 Abstract

Corona's misfortune is affecting the whole world. It causes fatal respiratory diseases and threatens public safety and human health. Scientists are scrambling to find effective drugs against SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). hunt Dietary supplements to treat coronavirus are a large area of scientific research. Grapefruit (GF) (Rutaceae) A subtropical fruit with strong bioactivity. Natural Grapefruit Seed Extract (GFSE) has proven beneficial healing properties effect. The purpose of this review is to collect published studies demonstrating antibacterial, antifungal, and antiviral activity. GFSE and its bioactive components, and their ability to inhibit SARS-CoV-2 activity. GFSE pair Gram-positive bacteria (Enterococcus and Staphylococcus) and Gram-negative bacteria (Escherichia coli and Pseudomonas) Pseudomonas aeruginosa). In addition, it exhibits a zone of inhibition against multidrug-resistant (MDR) bacteria. The antiviral activity of GFSE Nasal Spray turned out to be resistant to the new coronavirus. the anti-coronavirus potential of key components of GFSE such as naringenin, Resveratrol, limonin, and hesperidin have also been tried. In conclusion, additional clinical and in vivo studies are needed. GFSE (spray or syrup) is effective against SARS-CoV-2.

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 Keywords

Corona, Anti-viral, grapefruit, seed extract, anti-bacterial

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Creative Commons Attribution 4.0 and The Open Definition

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This article provides an overview of the benefits of orally disintegrating tablets (ODTs), as well as important considerations when evaluating ODTs, including bioequivalence, obstacles and restrictions, and lastly the present and future of ODTs. ODTs are in high demand, and the field is one that the pharmaceutical industry is developing quickly. These tablets melt or disintegrate in the mouth when placed there without the need for extra water. ODTs degrade when placed on the tongue. the medicine is instantly released, dissolving or dispersing in the saliva. As saliva descends into the stomach, some medications are absorbed from the mouth, pharynx, and oesophagus. When this occurs, a drug's bioavailability is much higher than what is seen from are becoming more and more respected in both business and academics. Their increasing significance was recently shown when the European Pharmacopoeia introduced the "Orodispersible Tablet" refers to a tablet that must be placed in the mouth for quick dispersion before being swallowed. ODTs face some difficulties, but this study demonstrates ways to deal with them.

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The present research is aimed to evaluating the effect of fibre Volume fraction and fibre orientation on mechanical properties of Epoxy based E-Glass Reinforced Bio Composites using Finite Element Method, particularly using ANSYS 14.5 Software. An effort is made to understand the behaviour of E-glass reinforced Bio-Composites by considering the fibre Volume Fraction as 10%, 20%, 30% and 40%. We aimed to set up a mathematical, computer-based model using finite element analysis simulation software, ie ANSYS 14.5. The plate or shell type element were used to prepare the specimen according to ASTM principles D-3039/D-3039M-00. Tensile and Buckling tests were simulated to evaluate mechanical properties such as tensile and Buckling strength, yield strength, from this study the fibre Volume Fraction of 10% will be the promising the component for highest Ultimate strength. Then keeping constant 10% fibre Volume Fraction, then by evaluating the different orientation for Various Layup Sequences such as [0/0/0/0], [90/90/90/90], [0/90/90/0], [0/90/0/90], [90/0/0/90], [30/-30/30/-30], [45/-45/45/-45], [60/-60/60/-60] for Ultimate Tensile and Buckling Strength, the fibre Layup Sequences [0/90/0/90] shows the very near by value of Ultimate Tensile Strength that is approximately equal to Human Tibia Bone.

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 Keywords

E-Glass fibre reinforced, Epoxy, Tibia Human Bone, Fibre Volume Fraction, Fibre Layup Sequences.

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Creative Commons Attribution 4.0 and The Open Definition

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Triphala, Devdaru, Daruhaldi, Nagarmotha, Kapaj Prameha

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Standardization, Herbal drug, WHO, Evaluation method , Quality control.

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Levofloxacin belongs to class fluoroquinolone. The formulation was prepared with the polymer as a base that is white petroleum jelly. Levofloxacin is an anti-bacterial drug. The main goal including enhanced potency against gram-positive cocci, streptococcus pneumoniae and anaerobes, while maintaining the potency against gram positive bacteria. The preparation of anti-bacterial ophthalmic ointment by using levofloxacin drug is evaluated by physical parameters, pH, spreadability, extrudability, viscosity. The in-vitro study is evaluated by Franz diffusion cell apparatus. The main objective of this formulation is to increase the stability, and prolonged action of ointment during the anti-bacterial infection in the eye and increase the patient compliance. It can be reasonably concluded that the levofloxacin ophthalmic ointment is better suited for prolonged release of levofloxacin.

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Levfloxacin, ointment, Eye

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Caryedon, development, Tamarindus

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Chemotherapy is a group of drugs for variety of indications are prescribed in oncology department. they are associated with many potential adverse drug reactions. neutropenia and febrile neutropenia are typically a symptom of an underling disease [AML] in the body rather than an illness on its own. A 65 year old female patient was admitted in oncology department, with a chief complaints of buccal swelling with pain, nausea, loss of appetite, oral mucositis with pain, high grade of fever with spikes which was raised as an adverse drug reactions of AZACITIDINE and VENETOCLAX which has been used for her AML [ acute myeloid leukemia]. this adverse reaction is considered as dose related type A ADR as per WHO scale. Azacytidine and venetoclax causes decrease in WBC count [neutrophils] which further causes neutropenia. Thus the hint of written report is to create awareness about chemotherapy drugs

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Neutropenia, chemotherapy, azacytidine, venetoclax, ADRs

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

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Creative Commons Attribution 4.0 and The Open Definition

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Anonymity, multi-authority, attribute-based encryption, AnonyControl

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

SHASAKIY EVAN ASHASAKIY PRATHAMIK STAR KE VIDHALAY MEIN GUNAVATTAPURN SHIKSHA KE KRIYANVAYAN KA ADHYAYAN

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SHASAKIY EVAN ASHASAKIY PRATHAMIK STAR KE VIDHALAY MEIN GUNAVATTAPURN SHIKSHA KE KRIYANVAYAN KA ADHYAYAN

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Creative Commons Attribution 4.0 and The Open Definition